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| Benvenutti,Régis Carlos; Gomes,Denise B.; Zanchet,Barbara; Locateli,Gelvani; Vechia,Cristian Alex Dalla; Zanotelli Serpa,Patrícia; Lutinski,Junir; Rodrigues Junior,Sinval Adalberto; Schönell,Amanda Patrícia; Diel,Kriptsan Abdon Poletto; Miorando,Daniela; Ernetti,Jackeline; Alves,Bianca de Oliveira; Zilli,Gabriela Adriany Lisboa; Banzato,Thais Petrochelli; Ruiz,Ana Lúcia Tasca Gois; Vidal Gutiérrez,Max; Vilegas,Wagner; Roman Junior,Walter Antônio. |
| Abstract Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigão. The leaves are popularly used as anti-inflammatory, antirheumatic and in the treatment of gastric disorders. However, the antiproliferative potential of this plant against human tumor cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of U. baccifera leaves extracts and fractions against a panel of human tumor cell lines in vitro besides a chemical evaluation of the most active sample by mass spectrometry (ESI-IT-MSn). The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antitumor agents; Medicinal plants; Chemical analysis. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100412 |
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| Cola-Miranda,Maira; Barbastefano,Victor; Hiruma-Lima,Clélia Akiko; Calvo,Tamara Regina; Vilegas,Wagner; Brito,Alba Regina Monteiro Souza. |
| The genus Indigofera (Fabaceae) is used in folk medicine to treat gastrointestinal pain. In this study, we investigated the antiulcerogenic properties of Indigofera truxillensis Kunth. Oral administration of MeOH extract did not produce any signals of acute toxicity. The antiulcerogenic activity was assessed in different models of acute gastric ulcers (100% ethanol, piroxicam 30 mg.kg-1, hypothermic restraint stress and pylorus ligature) in mice and rats. The animals were treated with the drugs lanzoprazole (30 mg.kg-1) or cimetidine (100 mg.kg-1) as positive controls depending on the performed model. In another experiment with ethanol-induced ulcers in rats, N-ethylmaleimide (NEM), a sulfhydryl group blocker, was also used. The MeOH extract, at doses of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antiulcerogenic activity; Fabaceae; Indigofera truxillensis Kunth; Medicinal plant; Phenolic compounds. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032006000300004 |
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| Roque,Nidia F.; Vilegas,Wagner; Gianella,Tania L.; Knudsen,Fernanda da S.; Rondella,Gisele P.; Torres,Luce Μ. B.; Ferro,Vicente O.; Oliveira,F.. |
| Das partes áereas das espécies vegetais Mikania triangularis, M. diversifolia, M. smilacina, M.microlepsis e Wedelia paludosa (Compositae) foram isolados ácidos diterpênicos em grande quantidade. Estes ácidos devem estar correlacionados às ações medicinais atribuídas a essas espécies. Da espécie Solidago microglossaisolou-se, como constituinte principal do extrato etanólico das partes áereas, a quercetrina, glicosídeo de reconhecida atividade contra a fragilidade capilar, justificando em parte o emprego desta substituição à Arnica montana. |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 1988 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59671988000500473 |
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| Santos,Lourdes Campaner dos; Dokkedal,Anne L.; Sannomiya,Miriam; Soares,Maria Carla Piza; Vilegas,Wagner. |
| This work presents the study of nonpolar compounds from plants belonging to the genus Paepalanthus Mart. (Eriocaulaceae). Long-chain linear aliphatic hydrocarbons were identified by GC-FID and GC-MS. The results indicate that Paepalanthus subg. Platycaulon species present a very homogenous profile, with carbon chains of n-alkanes ranging from C25 to C31, most samples presenting higher frequencies of C27 and C29 homologues. Paepalanthus subg. Paepalocephalus species may be distinguished from one another by the distribution of main n-alkanes. P. macrocephalus, subsect. Aphorocaulon species, presents alkanes with odd-carbon numbers and P. denudatus and P. polyanthus, Actinocephalus species, present alkanes with quite distinctive profiles, with many shorter... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Paepalanthus; N-alkanes; GC-FID; GC-MS; Chemotaxonomy. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062005000400007 |
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